Disease, disaster, and disability plagued the Stuart Family during the period they ruled England, 1603 to 1714. Dementia in James I, the beheading of Charles I, acute mercury poisoning in Charles II, a nosebleed in James II, acute hemorraghic smallpox in Mary II and lupus erythematosus in Queen Anne took them "off the throne", one by one.
My uncle Fred is a retired Doctor and is pioneering a new breed of Medical Historians.